March 2024

Moïra B. Dion1,2, Frank Oechslin1,2 and Sylvain Moineau1,2,3 1 Département de biochimie, de microbiologie et de bio-informatique, Faculté des sciences et de génie, Université Laval, Québec City, G1V 0A6, Canada1 加拿大魁北克市拉瓦尔大学科学与工程学院生物化学、微生物学和生物信息学系，G1V 0A6 2 Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Université Laval, Québec City, G1V 0A6, Canada2 加拿大魁北克市 G1V 0A6 拉瓦尔大学牙科学院口腔生态研究小组 3 Félix d’Hérelle Reference Center

Abstract 摘要 Phage therapy is one of the alternatives to treat infections caused by both antibiotic-sensitive and antibiotic-resistant bacteria, with no or low toxicity to patients. It was started a century ago, although rapidly growing bacterial antimicrobial resistance, resulting in high levels of morbidity, mortality, and financial cost, has initiated the revival of phage therapy. It

Opinion 意见 Evolutionary Rationale for Phages as Complements of Antibiotics噬菌体与抗生素互补的进化原理 Clara Torres-Barceló1,* and Michael E. Hochberg1,2,*Clara Torres-Barceló1,* 和 Michael E. Hochberg1,2,* Trends 发展趋势 The efficacy of new and old antibiotics could be preserved if combined with phages.如果与噬菌体结合使用，新旧抗生素的功效都能得到保留。 Positive interactions have been observed between antibiotics and lytic phages in controlling bacterial pathogens both in vitro and in vivo.在体外和体内，都观察到抗生素和溶菌噬菌体在控制细菌病原体方面的良性相互作用。