Phage Therapy in Livestock and Companion Animals家畜和伴侣动物中的噬菌体治疗

3. Phage Therapy in the Veterinary Field
3.兽医领域的噬菌体治疗

The use of antibiotics in veterinary medicine has been especially irrational during the last few years. Due to the emergence of MDR bacteria, it has become a major problem in this field. Phage therapy has been proposed as one of the most promising alternatives for the treatment of infections in animals to address this problem. Some examples of veterinary use of phage therapy are summarized in Table 1.
在过去的几年里，抗生素在兽医中的使用尤其不合理。由于MDR细菌的出现，它已成为该领域的一个主要问题。噬菌体疗法已被提出作为治疗动物感染以解决该问题的最有前途的替代方案之一。表1中总结了噬菌体治疗的兽医用途的一些实例。

Table 1 表1

Some studies about phage therapy in livestock and companion animals.
家畜和伴侣动物噬菌体治疗的一些研究。

Animals 动物	Infection 感染	Pathogen 病原体	Phages 噬菌体	Paper 纸
Bovines 牛	Mastitis 乳腺炎	S. aureus S.金黄色	ISP phage  ISP噬菌体	[53] [五十三]
			Phage cocktail 噬菌体混合物	[54,55] [ 54、55]
	Metritis 子宫炎	E. coli E.杆菌	Phage cocktail  噬菌体混合物	[56] [ 56个]
	Haemorragic septicemia 出血性败血症	P. mutocida P.穆托西达	PMP-GAD-IND phage  PMP-GAD-IND噬菌体	[57] [五十七]
Swine 猪	Diarrhea 腹泻	Salmonella sp.  沙门氏菌	Phage cocktail  噬菌体混合物	[58] [ 58个]
	Chronic wounds 慢性伤口	Multibacterial biofilms 多菌生物膜	Phage cocktail 噬菌体混合物	[59] [ 59个]
Mice 小鼠	Lung infection 肺部感染	P. aeruginosa P.铜绿	Phage PELP20  噬菌体PELP 20	[60] [ 60个]
		A. baumannii A.鲍曼不	φkm18p phage  φkm18p噬菌体	[61] [第六十一届]
	Septicemia 败血症	S. aureus S.金黄色	Phage s13’  噬菌体s13′	[62] [六十二]
	Systemic infection 全身感染	A. baumannii A.鲍曼不	LysSS  赖氨酸S	[46] [ 46个]
		K. pneumoniae	Dp42	[52]
Rabbits	Cholera-like diarrhea	V. cholerae	Phage cocktail	[63]
Dogs	Otitis externa	P. aeruginosa	Phage cocktail	[64]
	Urinary tract infections	P. aeruginosa	Pbunavirus PB1-like phages cocktail	[65]
		E. coli	5 promising single phages	[66]
	Wound infection	P. aeruginosa	Pbunavirus PB1-like phages cocktail	[65]
	Opportunistic bacteria in immunocompromised patients	E. coli	Phage HP3	[32]
Cats	Urinary tract infection	E. coli	5 promising single phages	[66]
Horses	Keratitis	P. aeruginosa	Phage cocktail	[67]
Bearded dragons	Pet-associated salmonellosis	Salmonella sp.	Felix O1 phage	[68]

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