2022 年 6 月 9 日
纽约–Phase Genomics公司周四表示，该公司已获得550万美元的资助，用于开发基于其噬菌体-细菌相互作用组资源库的噬菌体疗法预测发现引擎。
Phase公司将利用这笔资金（其中包括比尔及梅琳达-盖茨基金会提供的350万美元和美国国家过敏与传染病研究所提供的200万美元），使用其ProxiMeta近端引导元基因组学平台建立噬菌体-细菌相互作用图谱。然后，这家总部位于西雅图的公司将开发基于人工智能的工具，以识别可用于治疗的噬菌体，如治疗艰难梭菌感染、溃疡性结肠炎和克罗恩病。
Phase 说，这项技术还具有监测废水中耐药病原体的潜力。
“Phase公司创始人兼首席执行官伊万-利亚奇科（Ivan Liachko）在一份声明中说：”利用病毒和细菌相互作用的知识潜力巨大。”我们计划将新的噬菌体图谱作为一种资源，帮助应对病原体爆发和其他生物威胁，包括过度使用抗生素导致的耐药性。
新资金是继 2021 年初从美国国立卫生研究院获得 170 万美元赠款后的又一笔资金，用于开发一个发现新型病毒的平台，以开发治疗药物。
Phase Genomics Wins $5.5M in NIH, Gates Foundation Grants for Therapeutic Phage Discovery
Jun 09, 2022 |
NEW YORK — Phase Genomics said on Thursday that it has received $5.5 million in grant funding to develop a predictive discovery engine for phage therapeutics based on its phage-bacteria interactome repository.
With the funding — which includes $3.5 million from the Bill and Melinda Gates Foundation and $2 million from the National Institute of Allergy and Infectious Diseases — Phase will use its ProxiMeta proximity-guided metagenomics platform to build an atlas of phage-bacteria interactions. The Seattle-based company will then develop artificial intelligence-based tools to identify phages that can be used for therapeutic applications such as the treatment of Clostridioides difficile infections, ulcerative colitis, and Crohn’s disease.
The technology also holds potential for monitoring wastewater for treatment-resistant pathogens, Phase said.
“The potential to leverage the knowledge of how viruses and bacteria interact is immense,” Phase Founder and CEO Ivan Liachko said in a statement. “We plan for the new phage atlas to serve as a resource to help combat pathogen outbreaks and other biological threats, including drug resistance caused by the overuse of antibiotics.”
The new funding follows a $1.7 million grant Phase received in early 2021 from the National Institutes of Health to develop a platform for the discovery of novel viruses that can be used to develop therapeutics.
View source version – https://www.genomeweb.com/sequencing/phase-genomics-wins-55m-nih-gates-foundation-grants-therapeutic-phage-discovery